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These are the most downloaded papers for the 30 days preceding February 5, 2012.

1. Hallmarks of Cancer: The Next Generation
 Douglas Hanahan, Robert A. Weinberg
Summary | |
4 March 2011
144(5)
2. Generation of Chimeric Rhesus Monkeys
 Masahito Tachibana, Michelle Sparman, Cathy Ramsey, Hong Ma, Hyo-Sang Lee, Maria Cecilia T. Penedo, Shoukhrat Mitalipov
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20 January 2012
148(1)
3. Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
 Thomas A. Rando, Howard Y. Chang
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20 January 2012
148(1)
4. Funding in 2012: “Great Recession” Starts to Bite
 Colin Macilwain
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20 January 2012
148(1)
5. Waves of Retrotransposon Expansion Remodel Genome Organization and CTCF Binding in Multiple Mammalian Lineages
 Dominic Schmidt, Petra C. Schwalie, Michael D. Wilson, Benoit Ballester, Ângela Gonçalves, Claudia Kutter, Gordon D. Brown, Aileen Marshall, Paul Flicek, Duncan T. Odom
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20 January 2012
148(1)
6. Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome
 Tom Sexton, Eitan Yaffe, Ephraim Kenigsberg, Frédéric Bantignies, Benjamin Leblanc, Michael Hoichman, Hugues Parrinello, Amos Tanay, Giacomo Cavalli
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3 February 2012
148(3)
7. Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis
 Wen Cai Zhang, Ng Shyh-Chang, He Yang, Amit Rai, Shivshankar Umashankar, Siming Ma, Boon Seng Soh, Li Li Sun, Bee Choo Tai, Min En Nga et al.
Summary | |
20 January 2012
148(1)
8. EMT and Dissemination Precede Pancreatic Tumor Formation
 Andrew D. Rhim, Emily T. Mirek, Nicole M. Aiello, Anirban Maitra, Jennifer M. Bailey, Florencia McAllister, Maximilian Reichert, Gregory L. Beatty, Anil K. Rustgi, Robert H. Vonderheide et al.
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20 January 2012
148(1)
9. Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations
 Tobias Rausch, David T.W. Jones, Marc Zapatka, Adrian M. Stütz, Thomas Zichner, Joachim Weischenfeldt, Natalie Jäger, Marc Remke, David Shih, Paul A. Northcott et al.
Summary | |
20 January 2012
148(1)
10. Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
 Liming Sun, Huayi Wang, Zhigao Wang, Sudan He, She Chen, Daohong Liao, Lai Wang, Jiacong Yan, Weilong Liu, Xiaoguang Lei et al.
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20 January 2012
148(1)
11. Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory
 Amitabha Majumdar, Wanda Colón Cesario, Erica White-Grindley, Huoqing Jiang, Fengzhen Ren, Mohammed “Repon” Khan, Liying Li, Edward Man-Lik Choi, Kasthuri Kannan, Fengli Guo et al.
Summary | |
3 February 2012
148(3)
12. Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation
 Guoliang Li, Xiaoan Ruan, Raymond K. Auerbach, Kuljeet Singh Sandhu, Meizhen Zheng, Ping Wang, Huay Mei Poh, Yufen Goh, Joanne Lim, Jingyao Zhang et al.
Summary | |
20 January 2012
148(1)
13. Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
 Sung-Jun Park, Faiyaz Ahmad, Andrew Philp, Keith Baar, Tishan Williams, Haibin Luo, Hengming Ke, Holger Rehmann, Ronald Taussig, Alexandra L. Brown et al.
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3 February 2012
148(3)
14. A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
 Leonardo Salmena, Laura Poliseno, Yvonne Tay, Lev Kats, Pier Paolo Pandolfi
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5 August 2011
146(3)
15. Chimeric Primates: Embryonic Stem Cells Need Not Apply
 Alan Trounson, Uta Grieshammer
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20 January 2012
148(1)
16. The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways
 Zhigao Wang, Hui Jiang, She Chen, Fenghe Du, Xiaodong Wang
Summary | |
20 January 2012
148(1)
17. Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration
 Andrew R. Houk, Alexandra Jilkine, Cecile O. Mejean, Rostislav Boltyanskiy, Eric R. Dufresne, Sigurd B. Angenent, Steven J. Altschuler, Lani F. Wu, Orion D. Weiner
Summary | |
20 January 2012
148(1)
18. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons
 Lishi Li, Michael Rutlin, Victoria E. Abraira, Colleen Cassidy, Laura Kus, Shiaoching Gong, Michael P. Jankowski, Wenqin Luo, Nathaniel Heintz, H. Richard Koerber et al.
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23 December 2011
147(7)
19. Connecting Threads: Epigenetics and Metabolism
 Sayako Katada, Axel Imhof, Paolo Sassone-Corsi
Summary | |
20 January 2012
148(1)
20. RNA Dynamics in Aging Bacterial Spores
 Einat Segev, Yoav Smith, Sigal Ben-Yehuda
Summary | |
20 January 2012
148(1)