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Volume 18, Issue 1

What interconnected pathways can explain the behavior of cancer cells? In this month’s Focus issue, six articles discuss the ways cancer cells control growth, resistance, invasion, metastasis, and more. In a Feature Review on pages 13–26 Stephanie Alexander and Peter Friedl summarize the commonalities between pathways that control resistance to therapies as well as invasion and metastasis. In the field of cancer therapies, Zhenyu Ji, Keith Flaherty, and Hensin Tsao review new compounds for targeting the RAS pathway in melanoma (pages 27–35), and Valerie Lallemand-Breitenbach, Jun Zhu, Zhu Chen, and Hugues de Thé explain the mechanism behind the As2O3/retinoic acid cure for APL (pages 36–42). On pages 43–51, Taras Stasyk and Lukas Huber review the latest in phosphoproteomics and how these methods can help identify signal transduction pathways in vivo, from samples such as patient tissues and organs. Finally, in the first example of our new Spotlight format, Stefano Fais and Marie-Odile Fauvarque highlight novel mechanisms underlying the phagocytosis of neighboring cells by metastatic cancer cells. Cover image: Tumor cells on the move, courtesy of Stephanie Alexander and Peter Friedl. In green is the cytoplasm of tumor cells, surrounded by blood vessels in red and collagen fibrils in blue.

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Current Issue January 2012 | Volume 18, Issue 1 Focus Issue: Cancer Register for TMM Table of Contents alerts here.

What interconnected pathways can explain the behavior of cancer cells? In this month’s Focus issue, six articles discuss the ways cancer cells control growth, resistance, invasion, metastasis, and more. In a Feature Review Stephanie Alexander and Peter Friedl summarize the commonalities between pathways that control resistance to therapies as well as invasion and metastasis. In the field of cancer therapies, Zhenyu Ji, Keith Flaherty, and Hensin Tsao review new compounds for targeting the RAS pathway in melanoma, and Valerie Lallemand-Breitenbach, Jun Zhu, Zhu Chen, and Hugues de Thé explain the mechanism behind the As2O3/retinoic acid cure for APL. Taras Stasyk and Lukas Huber review the latest in phosphoproteomics and how these methods can help identify signal transduction pathways in vivo, from samples such as patient tissues and organs. Finally, in the first example of our new Spotlight format, Stefano Fais and Marie-Odile Fauvarque highlight novel mechanisms underlying the phagocytosis of neighboring cells by metastatic cancer cells. Cover image: Tumor cells on the move, courtesy of Stephanie Alexander and Peter Friedl. In green is the cytoplasm of tumor cells, surrounded by blood vessels in red and collagen fibrils in blue.

	Cancer Articles Feature Review Cancer invasion and resistance: interconnected processes of disease progression and therapy failure Stephanie Alexander & Peter Friedl Review Curing APL through PML/RARA degradation by As2O3 Valerie Lallemand-Breitenbach, Jun Zhu, Zhu Chen, & Hugues de Thé Review Mapping in vivo signal transduction defects by phosphoproteomics Taras Stasyk & Lukas A. Huber
	Review Targeting the RAS pathway in melanoma Zhenyu Ji, Keith T. Flaherty, & Hensin Tsao Opinion The emerging role of p53 in stem cells Giuseppina Bonizzi, Angelo Cicalese, Alessandra Insinga, & Pier Giuseppe Pelicci Spotlight TM9 and cannibalism: how to learn more about cancer by studying amoebae and invertebrates Stefano Fais & Marie-Odile Fauvarque
	Review Endoplasmic reticulum stress, obesity and diabetes Miriam Cnop, Fabienne Foufelle, & Licio A. Velloso Review Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism Sabrina Diano & Tamas L. Horvath Science & Society HDBuzz: empowering patients through accessible education Edward Wild & Jeffrey Carroll

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Resources

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Neuron Primers

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Most Read Articles Article Feed

These are the five most downloaded papers for the 30 days preceding February 5, 2012. See full list of most read articles

Cancer invasion and resistance: interconnected processes of disease progression and therapy failure

Stephanie Alexander, Peter Friedl
10.1016/j.molmed.2011.11.003

Summary | |

The emerging role of p53 in stem cells

Giuseppina Bonizzi, Angelo Cicalese, Alessandra Insinga, Pier Giuseppe Pelicci
10.1016/j.molmed.2011.08.002

Summary | |

Endoplasmic reticulum stress, obesity and diabetes

Miriam Cnop, Fabienne Foufelle, Licio A. Velloso
10.1016/j.molmed.2011.07.010

Summary | |

DISC1 at 10: connecting psychiatric genetics and neuroscience

David J. Porteous, J. Kirsty Millar, Nicholas J. Brandon, Akira Sawa
10.1016/j.molmed.2011.09.002

Summary | |

Targeting the RAS pathway in melanoma

Zhenyu Ji, Keith T. Flaherty, Hensin Tsao
10.1016/j.molmed.2011.08.001

Summary | |